Ming-Shiang WuDirector

Dr. Ming-Shiang Wu is a Distinguished Professor of Internal Medicine and the Director at the National Taiwan University College of Medicine. He also serves as President of the Taiwan Medical Association and the Taiwan Association of Internal Medicine. His primary research areas include gastroenterology, molecular biology, Helicobacter pylori, and gut microbiota studies. Dr. Wu has an outstanding academic record, with over 500 published papers and has received numerous national and international awards, including the Ministry of Science and Technology’s Wu Ta-You Memorial Award and Outstanding Research Award. He has also been honored as a Fellow of the Industrial Technology Research Institute. Currently, he is an editor for international journals such as Gut and Gastric Cancer.

  • 著作：
  1. Chen, Y.-C., Malfertheiner, P., Yu, H.-T., Kuo, C.-L., Chang, Y.-Y., Meng, F.-T., Wu, Y.-X., Hsiao, J.-L., Chen, M.-J., Lin, K.-P., Wu, C.-Y., Lin, J.-T., Colm O’Morain, Megraud, F., Lee, W.-C., El-Omar, E. M., Wu, M.-S., & Liou, J.-M. (2024). Global prevalence of Helicobacter pylori infection and incidence of gastric cancer between 1980 and 2022. Gastroenterology, 166(4). https://doi.org/10.1053/j.gastro.2023.12.022
  2. Hong, T.-C., El-Omar, E. M., Kuo, Y.-T., Wu, J.-Y., Chen, M.-J., Chen, C.-C., Fang, Y.-J., Hwong, A., Lu, H., Lin, J.-T., Tu, Y.-K., Yamaoka, Y., Wu, M.-S., Liou, J.-M., Hong, T.-C., El-Omar, E. M., Kuo, Y.-T., Wu, J.-Y., Chen, M.-J., & Chen, C.-C. (2024). Primary antibiotic resistance of Helicobacter pylori in the Asia-Pacific region between 1990 and 2022: an updated systematic review and meta-analysis. ˜the œLancet. Gastroenterology & Hepatology, 9(1), 56–67. https://doi.org/10.1016/s2468-1253(23)00281-9
  3. Lyu, Q., Chen, R.-A., Chuang, H.-L., Zou, H.-B., Liu, L., Sung, L.-K., Liu, P.-Y., Wu, H.-Y., Chang, H.-Y., Cheng, W.-J., Wu, W.-K., Wu, M.-S., & Hsu, C.-C. (2024). Bifidobacterium alleviate metabolic disorders via converting methionine to 5’-methylthioadenosine. Gut Microbes, 16(1). https://doi.org/10.1080/19490976.2023.2300847
  4. Chen, P.-Y., Tsai, F.-P., Chen, M.-J., Yang, H.-Y., Wu, M.-S., & Liou, J.-M. (2023). Vonoprazan-based versus proton pump inhibitor-based therapy inHelicobacter pylorieradication: an updated systematic review and meta-analysis of randomised trials. Gut, gutjnl-329826. https://doi.org/10.1136/gutjnl-2023-329826
  5. Chen, M.-J., Bair, M.-J., Chen, P.-Y., Lee, J.-Y., Yang, T.-H., Fang, Y.-J., Chen, C.-C., Chang, A.-T., Hsiao, W.-D., Yu, J.-J., Kuo, C.-C., Chiu, M.-C., Lin, K.-P., Tsai, M.-H., Hsu, Y.-C., Chou, C.-K., Chen, C.-Y., Lin, J.-T., Lee, Y.-C., & Wu, M.-S. (2022). Declining trends of prevalence ofHelicobacter pyloriinfection and incidence of gastric cancer in Taiwan: An updated cross‐sectional survey and meta‐analysis. Helicobacter, 27(5). https://doi.org/10.1111/hel.12914
  6. Suraphan Panyod, Wu, W.-K., Hsieh, Y.-C., Tseng, Y.-J., Peng, S.-Y., Chen, R.-A., Huang, H.-S., Chen, Y.-H., Ting-Chin David Shen, Ho, C.-T., Liu, C.-J., Chuang, H.-L., Huang, C.-C., Wu, M.-S., & Sheen, L.-Y. (2024). Ginger essential oil prevents NASH progression by blocking the NLRP3 inflammasome and remodeling the gut microbiota-LPS-TLR4 pathway in mice. Nutrition and Diabetes, 14(1). https://doi.org/10.1038/s41387-024-00306-1
  7. Lei, W., Lee, J.-Y., Chuang, S., Bair, M., Chen, C., Jeng Yih Wu, Wu, D., Felice Tien O’Donnell, Tien, H.-W., Chen, Y.-R., Chiang, T., Hsu, Y., Hsu, T., Hsieh, P.-C., Lin, L., Chia, S., Wu, C.-C., Yi‐Maun Subeq, Wen, S., & Chang, H.-C. (2023). EradicatingHelicobacter pylorivia13C-urea breath screening to prevent gastric cancer in indigenous communities: a population-based study and development of a family index-case method. Gut, 72(12), 2231–2240. https://doi.org/10.1136/gutjnl-2023-329871
  8. Chen, S.-J., Wu, Y.-J., Chen, C.-C., Wu, Y.-W., Liou, J.-M., Wu, M.-S., Kuo, C.-H., & Lin, C.-H. (2023). Plasma metabolites of aromatic amino acids associate with clinical severity and gut microbiota of Parkinson’s disease. Npj Parkinson S Disease, 9(1). https://doi.org/10.1038/s41531-023-00612-y
  9. Liu, W.-D., Wang, J.-T., Shih, M.-C., Chen, K.-H., Huang, S.-T., Huang, C.-F., Chang, T.-H., Tsai, M.-J., Kuo, P.-H., Yeh, Y.-C., Tsai, W.-C., Pan, M.-Y., Li, G.-C., Chen, Y.-J., Lin, K.-Y., Huang, Y.-S., Cheng, A., Chen, P.-Y., Pan, S.-C., & Sun, H.-Y. (2024). Effect of Early Dexamethasone on Outcomes of COVID-19: A Quasi-experimental Study Using Propensity Score Matching. Journal of Microbiology Immunology and Infection. https://doi.org/10.1016/j.jmii.2024.02.002
  10. Lee, Y.-C., Chiang, T.-H., Chiu, H.-M., Su, W.-W., Chou, K.-C., Chen, S. L.-S., Yen, A. M.-F., Fann, J. C.-Y., Chiu, S. Y.-H., Chuang, S.-L., Chen, Y.-R., Chen, S.-D., Hu, T.-H., Fang, Y.-J., Wu, M.-S., Chen, T. H.-H., Yeh, Y.-P., Lin , J.-T., Wu, C.-Y., & Liou, J.-M. (2024). Screening for Helicobacter pylori to Prevent Gastric Cancer. JAMA. https://doi.org/10.1001/jama.2024.14887
  11. Chen, Y., Wu, M., Wang, S.-H., Yin Ju Lien, Liao, S., Chang, C., Huang, W., Wu, C., & Hsu, C. (2024). Effectiveness of health checkup with depression screening on depression treatment and outcomes in middle-aged and older adults: a target trial emulation study. The Lancet Regional Health – Western Pacific, 43, 100978–100978. https://doi.org/10.1016/j.lanwpc.2023.100978
  12. Suraphan Panyod, Wu, W.-K., Hu, M.-Y., Huang, H.-S., Chen, R.-A., Chen, Y.-H., Ting-Chin David Shen, Ho, C.-T., Liu, C.-J., Chuang, H.-L., Huang, C.-C., Wu, M.-S., & Sheen, L.-Y. (2024). Healthy diet intervention reverses the progression of NASH through gut microbiota modulation. Microbiology Spectrum, 12(1). https://doi.org/10.1128/spectrum.01868-23
  13. Chen, C.-C., Tseng, P.-H., Hsueh, H.-W., Chiang, M.-C., Tzeng, S.-R., Tsung Hsien Chiang, Wu, M.-S., Hsieh, S.-T., & Chao, C.-C. (2024). Altered gut microbiota in Taiwanese A97S predominant transthyretin amyloidosis with polyneuropathy. Scientific Reports, 14(1). https://doi.org/10.1038/s41598-024-56984-5
  14. Suraphan Panyod, Wu, W.-K., Chang, C.-T., Wada, N., Ho, H.-C., Lo, Y.-L., Tsai, S.-P., Chen, R.-A., Huang, H.-S., Liu, P.-Y., Chen, Y.-H., Chuang, H.-L., Ting-Chin David Shen, Tang, S.-L., Ho, C.-T., Wu, M.-S., & Sheen, L.-Y. (2024). Common dietary emulsifiers promote metabolic disorders and intestinal microbiota dysbiosis in mice. Communications Biology, 7(1). https://doi.org/10.1038/s42003-024-06224-3
  15. Hsu, W.-F., Chang, W.-Y., Kuo, C.-Y., Chang, L.-C., Lin, H.-H., Wu, M.-S., & Chiu, H.-M. (2024). The Effect of Novel AI-based Cecum Recognition System on Adenoma Detection Metrics at Screening Colonoscopy Setting. Gastrointestinal Endoscopy. https://doi.org/10.1016/j.gie.2024.09.019
  16. Liu, Y.-T., Wu, W.-H., Tseng, W.-T., Lin, H.-C., Wu, M.-S., Chen, P.-F., & Wu, I-Chien. (2023). Lower HbA1C of glycemic control is associated with higher risk of depressive symptoms in elderly with type 2 diabetes mellitus–A Nationwide Community-based study. Journal of Psychosomatic Research, 174, 111492. https://doi.org/10.1016/j.jpsychores.2023.111492
  17. Hu, K.-Y., Tseng, P.-H., Hsu, W.-C., Lee, P.-L., Tu, C.-H., Chen, C.-C., Lee, Y.-C., Chiu, H.-M., Wu, M.-S., & Peng, C.-K. (2024). Association of self-reported and objective sleep disturbance with the spectrum of gastroesophageal reflux disease. Journal of Clinical Sleep Medicine, 20(6), 911–920. https://doi.org/10.5664/jcsm.11028
  18. Lee, Y.-P., Chiu, C.-C., Chang, Y.-C., Chen, Y.-H., Wu, W.-K., Wu, M.-S., & Chuang, H.-L. (2024). Different bacteria species lipopolysaccharide co-exposure with NASH diet exacerbate NASH and liver fibrosis progress in mice. Clinics and Research in Hepatology and Gastroenterology, 102470. https://doi.org/10.1016/j.clinre.2024.102470
  19. Chou, C.-Y., Chiang, P.-C., Li, C.-C., Chang, J.-W., Lu, P.-H., Hsu, W.-F., Chang, L.-C., Hsu, J.-L., Wu, M.-S., & Wo, A. M. (2024). Improving the Purity of Extracellular Vesicles by Removal of Lipoproteins from Size Exclusion Chromatography- and Ultracentrifugation-Processed Samples Using Glycosaminoglycan-Functionalized Magnetic Beads. ACS Applied Materials & Interfaces. https://doi.org/10.1021/acsami.4c03869
  20. Liao, P.-H., Tung, H.-Y., Wee Shin Lim, Jyh-Shing Roger Jang, Li, H., Shun, C.-T., Chiu, H.-M., Wu, M.-S., & Lin, C.-H. (2024). Impaired gut barrier integrity and reduced colonic expression of free fatty acid receptors in patients with Parkinson’s disease. Neurological Sciences. https://doi.org/10.1007/s10072-024-07641-2
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